I always take all the pictures down then arrange the rest of the room. Then I look for inappropriate gaps and 'fill' them with wall art.
As we all know, too many pictures can crowd a room. I agree with everyone else, paint the frame black and this picture is fine. ..... maybe. There is a lot going on with that pic. Eye-catching red, two faces, a lot of motion, and potential recognition of that famous painting. It is going to momentarily catch the attention of almost any buyer. So, I would only use it if I could hang it near an architectural feature I wanted to hi lite - I would use it to pull eyes in it's direction so they could then see something important about the room.